targeted therapy Archives - Page 5 of 5

Acute Leukemia with Lysine Methyltransferase 2A Gene (KMT2A) Translocation

February 1, 2025

The lysine methyltransferase 2A gene (KMT2A), formerly known as MLL, plays a critical role in regulating histone H3K4 methylation, a process essential for transcriptional activation. Translocations

Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS)

January 4, 2025January 3, 2025

Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS) is a rare primary immunodeficiency caused by genetic mutations in the PIK3CD or PIK3R1 genes, which regulate the phosphoinositide