Proteus joint infections, though relatively uncommon compared to other causative agents, represent a serious clinical challenge, particularly in cases of prosthetic joint implantation or compromised host immunity. Proteus mirabilis, a motile, urease-producing gram-negative bacillus, is the predominant species implicated. Its capacity for biofilm formation and multidrug resistance necessitates a robust, evidence-based approach to diagnosis and
Proteus endometritis is an uncommon but clinically significant form of endometrial infection, primarily caused by Proteus mirabilis, a gram-negative facultative anaerobe. Typically associated with polymicrobial pelvic infections, this condition arises from ascending bacterial invasion of the uterine lining and often coexists with pelvic inflammatory disease (PID), postpartum infections, or post-instrumentation sepsis. Accurate diagnosis and targeted
Proteus cystitis represents a significant form of urinary tract infection (UTI) caused predominantly by Proteus mirabilis, a motile, gram-negative bacterium within the Enterobacteriaceae family. Known for its urease activity and propensity to form biofilms and urinary stones, Proteus species are especially concerning in patients with indwelling catheters or recurrent infections. Accurate recognition and effective treatment
Proteus bronchitis is a rare form of lower respiratory tract infection caused by the Proteus species, most notably Proteus mirabilis and Proteus vulgaris. While these gram-negative bacilli are commonly associated with urinary tract infections, their presence in the bronchial system can lead to significant clinical complications, particularly in immunocompromised individuals or patients with chronic pulmonary
Protein C deficiency is a rare but significant hereditary or acquired disorder of the coagulation system, characterized by an increased risk of thromboembolic events due to impaired natural anticoagulation. As a vital component of the protein C pathway, a deficiency in this protein disrupts the body’s ability to regulate blood clot formation, posing a substantial
Prosthetic heart valve endocarditis (PVE) remains a severe and potentially life-threatening condition in cardiology and cardiac surgery. Despite advancements in valve technology and antibiotic prophylaxis, it presents with high morbidity and mortality. We examine the etiology, pathophysiology, diagnosis, and current therapeutic strategies surrounding PVE, integrating current best practices and innovations. Overview of Prosthetic Valve Endocarditis
Prosthetic joint infections (PJIs) represent a significant challenge in orthopedic surgery, compromising patient outcomes and increasing healthcare costs. Preventing infections following prosthetic arthroplasty requires a multifaceted approach involving meticulous surgical technique, optimized patient selection, and evidence-based perioperative protocols. Understanding Prosthetic Joint Infections: Epidemiology and Impact PJIs occur in approximately 1–2% of primary joint replacements and
Prostatic carcinoma, commonly known as prostate cancer, remains a leading cause of cancer-related morbidity and mortality among men worldwide. Early detection, accurate staging, and evolving treatment modalities have significantly improved clinical outcomes. This article provides a comprehensive analysis of the disease’s pathology, clinical presentation, diagnostic strategies, therapeutic options, and emerging trends in management. Understanding Prostatic
Prostate cancer remains one of the most prevalent malignancies among men globally. Accurate detection of metastatic spread is essential for determining prognosis, guiding therapeutic choices, and evaluating treatment response. Imaging plays a pivotal role in the staging and surveillance of prostatic cancer, particularly in identifying distant metastases. In this comprehensive overview, we examine the latest
Propionic acidemia (PA) is a rare but serious inherited metabolic disorder belonging to the group of organic acidemias. It results from a deficiency in the enzyme propionyl-CoA carboxylase (PCC), which is essential for breaking down certain proteins and fats. Without this enzyme, toxic levels of propionic acid accumulate in the body, leading to severe metabolic