Pseudogout, medically known as calcium pyrophosphate deposition disease (CPPD), is an inflammatory joint condition characterized by the deposition of calcium pyrophosphate dihydrate crystals in the joints. These crystal deposits lead to episodes of joint pain and swelling, often mimicking gout, but with distinct pathophysiology and clinical implications. What Is Pseudogout? Understanding Calcium Pyrophosphate Deposition Disease
Pseudobulbar affect (PBA) is a neurological disorder characterized by sudden, involuntary episodes of laughing or crying that are disproportionate or unrelated to the individual’s actual emotional state. It is frequently misdiagnosed due to its overlap with mood disorders but remains a distinct clinical condition with a well-established neurological basis. Defining Pseudobulbar Affect: Clinical Profile and
Pruritus, or chronic itching of the skin, is a frequent dermatological and systemic complaint that significantly affects patient well-being. It may occur as a standalone symptom or be indicative of underlying dermatologic, neurologic, systemic, or psychogenic conditions. A precise understanding of the etiology and pathophysiology is crucial for effective treatment. Defining Pruritus: Clinical Presentation and
Pruritus, commonly referred to as itching, is a highly prevalent and distressing symptom in patients with end-stage renal disease (ESRD) undergoing hemodialysis. Known as uremic pruritus, this condition is underrecognized despite its significant impact on quality of life, sleep, and morbidity. A systematic, pathophysiologically informed approach to diagnosis and treatment is essential in managing pruritus
Progressive Familial Intrahepatic Cholestasis (PFIC) is a group of rare, genetically inherited liver disorders characterized by defective bile flow (cholestasis) beginning in infancy or early childhood. One of the most debilitating symptoms experienced by patients with PFIC is pruritus, or chronic itch, often leading to excoriations, sleep disturbances, and severely diminished quality of life. Effective
Pruritus ani is defined as an unpleasant sensation of itching localized to the perianal area, often resulting in an irresistible urge to scratch. This condition, though often underestimated, can significantly impair quality of life and poses a diagnostic challenge due to its multifactorial etiology. Understanding Pruritus Ani: Pathophysiology and Etiologic Factors Primary vs. Secondary Pruritus
Providencia urinary tract infections (UTIs) are significant contributors to complicated and nosocomial infections, particularly in patients with prolonged catheterization or weakened immunity. Members of the genus Providencia, primarily Providencia stuartii and Providencia rettgeri, are increasingly recognized for their resistance to multiple antibiotics, posing considerable challenges in clinical management. Overview of Providencia Species and Their Role
Prurigo nodularis (PN) is a chronic inflammatory skin condition marked by intensely itchy nodules, often arising from a cycle of persistent scratching and skin injury. As a distinct dermatological entity, PN imposes a considerable burden on quality of life and is frequently associated with underlying systemic or neurological conditions. Understanding Prurigo Nodularis: Etiology and Pathogenesis
Providencia septicemia, a rare but serious bloodstream infection, is increasingly reported among hospitalized patients, particularly those with indwelling devices or immunocompromised status. This condition, most commonly caused by Providencia stuartii and Providencia rettgeri, presents a growing clinical concern due to its inherent multidrug resistance and high morbidity in vulnerable populations. In this article, we examine
Providencia species, notably Providencia stuartii and Providencia rettgeri, are emerging pathogens responsible for complicated urinary tract infections (UTIs), particularly in healthcare settings. These Gram-negative bacilli pose significant clinical challenges due to their intrinsic resistance mechanisms and association with indwelling medical devices. This article provides a detailed review of Providencia complicated UTIs, from pathophysiology and diagnosis