Patients at Risk of Anaphylaxis

Anaphylaxis is a life-threatening systemic allergic reaction requiring immediate recognition and intervention. It can develop rapidly and may result in death if not promptly treated. Identifying patients at risk of anaphylaxis, understanding the underlying triggers, and implementing preventive strategies are crucial components of comprehensive clinical care. Recognizing Patients at Risk of Anaphylaxis Common Risk Factors

Pathological Gastric Acid Hypersecretory Condition

Pathological gastric acid hypersecretory condition refers to an abnormal increase in gastric acid production beyond physiological needs, often leading to severe gastrointestinal complications. This condition is primarily associated with diseases like Zollinger-Ellison syndrome, and is characterized by hypergastrinemia and excessive stimulation of parietal cells. Chronic acid overproduction disrupts mucosal integrity, increases ulcer formation risk, and

Pathologic Myopia

Pathologic myopia, also known as degenerative or malignant myopia, is a severe form of high myopia characterized by progressive and structural changes to the posterior segment of the eye. These changes include excessive axial elongation, thinning of the retina and choroid, posterior staphyloma, and macular atrophy, all of which contribute to irreversible visual impairment. Defined

Patent Ductus Arteriosus (PDA)

Patent ductus arteriosus (PDA) is a congenital cardiac anomaly in which the ductus arteriosus—a fetal blood vessel connecting the pulmonary artery to the aorta—fails to close after birth. This persistent opening leads to abnormal circulation between the systemic and pulmonary arteries, resulting in increased workload on the heart and lungs. During fetal development, the ductus

Pasteurellosis

Pasteurellosis is a zoonotic infection primarily caused by Pasteurella multocida, a Gram-negative, facultatively anaerobic coccobacillus. This bacterium is part of the normal flora in the upper respiratory tract and oral cavity of many domestic and wild animals. The infection can affect both humans and animals, presenting in a variety of forms ranging from mild localized

Pasteurella multocida Osteomyelitis

Pasteurella multocida osteomyelitis is an uncommon but serious infection of the bone caused by Pasteurella multocida, a facultative anaerobic, Gram-negative coccobacillus. This zoonotic pathogen is part of the normal oral flora of domestic animals, particularly cats and dogs. Human infection usually occurs following bites, scratches, or licks on broken skin, leading to local tissue infection

Pasteurella multocida Endocarditis

Pasteurella multocida endocarditis represents a rare but increasingly recognized form of zoonotic infective endocarditis. This Gram-negative, facultatively anaerobic coccobacillus is commonly found in the oropharyngeal flora of domestic animals, especially cats and dogs. Human infections typically follow animal bites, scratches, or close contact. Though commonly associated with soft tissue infections, Pasteurella multocida can invade deeper

Advanced Adjunctive Treatments for Partial Epilepsy

Partial epilepsy, also referred to as focal epilepsy, originates in a specific region of the cerebral cortex. Seizures can remain localized or evolve into generalized seizures. When first-line antiepileptic drugs (AEDs) fail to provide sufficient control, adjunctive treatments—used in combination with baseline therapy—offer critical support in reducing seizure frequency and improving quality of life. Adjunctive

Partial Central Diabetes Insipidus

Partial central diabetes insipidus is a subtype of central diabetes insipidus characterized by incomplete deficiency of arginine vasopressin (AVP), also known as antidiuretic hormone (ADH). Unlike complete CDI, where AVP secretion is nearly absent, the partial form involves a measurable but insufficient level of AVP production, leading to impaired water reabsorption and mild to moderate

Paroxysmal Supraventricular Tachycardia

Paroxysmal supraventricular tachycardia (PSVT) refers to a group of arrhythmias characterized by sudden-onset episodes of rapid heart rate originating above the ventricles. These arrhythmias can abruptly begin and end, with heart rates often ranging between 150 and 250 beats per minute. PSVT episodes can occur in structurally normal hearts and are frequently observed in young