Phenylketonuria (PKU)

Phenylketonuria (PKU) is a rare but serious autosomal recessive metabolic disorder that affects the body’s ability to metabolize the amino acid phenylalanine. Without prompt diagnosis and dietary intervention, PKU can result in irreversible intellectual disability and neurological impairment. This article presents a detailed, evidence-based overview of PKU, its pathophysiology, clinical features, diagnosis, management, and preventive

Pharyngitis Due to Streptococcus pyogenes

Pharyngitis Due to Streptococcus pyogenes: Pharyngitis caused by Streptococcus pyogenes, also known as Group A Streptococcus (GAS), represents one of the most common and clinically significant bacterial throat infections. Prompt diagnosis and treatment are essential to reduce symptoms, prevent complications, and limit transmission. Understanding Streptococcus pyogenes and Its Pathogenic Role Streptococcus pyogenes is a gram-positive,

Pharyngitis Due to Haemophilus parainfluenzae

Pharyngitis Due to Haemophilus parainfluenzae: Haemophilus parainfluenzae is an opportunistic, gram-negative bacterium commonly found in the upper respiratory tract. Though often part of the normal oropharyngeal flora, it has emerged as a significant pathogen implicated in pharyngeal infections. This form of pharyngitis can be clinically indistinguishable from viral or streptococcal pharyngitis, yet requires targeted antimicrobial

Pharyngitis

it is commonly referred to as a sore throat, is the inflammation of the pharynx — the anatomical region situated at the back of the throat. This condition, often triggered by viral or bacterial infections, affects individuals across all age groups. Pharyngitis may be acute or chronic, and understanding its underlying cause is vital for

Peyronie’s Disease

Peyronie’s disease is a noncancerous condition characterized by the development of fibrous scar tissue, or plaque, within the penis. This leads to abnormal curvature during erections, which may result in pain, erectile dysfunction, and significant psychological distress. While the exact prevalence is unclear due to underreporting, studies estimate that Peyronie’s disease affects approximately 1 in

Pertussis (Whooping Cough)

it is commonly known as whooping cough, is a highly contagious respiratory infection caused by Bordetella pertussis. This bacterial illness is characterized by severe coughing fits followed by a high-pitched “whoop” sound during inhalation. While it can affect individuals of all ages, infants under one year are at the highest risk of complications and mortality.

Persistent Pulmonary Hypertension of the Newborn (PPHN)

Persistent pulmonary hypertension of the newborn (PPHN) is a critical condition characterized by the failure of the normal circulatory transition that occurs after birth. It results in sustained elevated pulmonary vascular resistance (PVR), leading to right-to-left shunting of blood and severe hypoxemia. Immediate diagnosis and intervention are essential to reduce mortality and long-term morbidity. Understanding

Pernicious Anemia

Pernicious anemia is a form of megaloblastic anemia resulting from vitamin B12 deficiency due to impaired absorption in the gastrointestinal tract. It is classified as an autoimmune condition in which the body fails to produce intrinsic factor, a protein essential for vitamin B12 absorption in the ileum. Left untreated, pernicious anemia can lead to irreversible

Peritonitis

Peritonitis is a severe and potentially life-threatening inflammation of the peritoneum—the thin layer of tissue lining the inside of the abdominal wall and covering the abdominal organs. This condition demands urgent medical attention, as delayed treatment can result in systemic infection, organ failure, or death. Understanding Peritonitis: Definition and Clinical Overview Peritonitis occurs when the

Peripheral Vascular Disease (PVD)

Peripheral Vascular Disease (PVD), also referred to as Peripheral Artery Disease (PAD), is a circulatory disorder that affects the blood vessels outside the heart and brain, most commonly in the legs and arms. It leads to narrowed or blocked arteries, reducing blood flow and resulting in significant health complications if left untreated. What Is Peripheral