Opioid-Induced Constipation (OIC)
Opioid-induced constipation (OIC) is one of the most prevalent and distressing adverse effects of opioid therapy. Unlike other opioid side effects such as sedation or nausea that may diminish with time, OIC tends to persist throughout treatment and often worsens. It significantly affects patients’ quality of life, treatment adherence, and clinical outcomes, particularly in individuals