Non-24-Hour Sleep-Wake Cycle Disorder

Non-24-Hour Sleep-Wake Cycle Disorder (Non-24) is a chronic circadian rhythm disorder where the internal biological clock fails to align with the 24-hour day-night cycle. Most prevalent in individuals who are completely blind, the disorder results in progressively delayed sleep and wake times, severely impacting daily functioning and quality of life. While it commonly affects the

Non-Q Wave Myocardial Infarction (NQMI)

Non-Q Wave Myocardial Infarction (NQMI), a subset of acute coronary syndromes (ACS), represents a form of myocardial infarction without the classic Q wave development on electrocardiogram (ECG). While it does not exhibit full-thickness myocardial necrosis, it signifies a serious ischemic event requiring urgent intervention. NQMI is typically classified under non-ST elevation myocardial infarction (NSTEMI) and

Nocturnal Enuresis

Nocturnal enuresis, commonly known as bedwetting, is a condition characterized by involuntary urination during sleep. It primarily affects children but can persist into adolescence and adulthood. While occasional episodes are normal in young children, persistent bedwetting may indicate an underlying medical or psychological issue. Understanding the causes, symptoms, and treatment options can help manage and

Nocturia

Nocturia is a urinary disorder characterized by frequent urination during the night, disrupting sleep and affecting overall well-being. Unlike typical nighttime awakenings, nocturia involves waking up two or more times to urinate. This condition is often linked to aging, medical conditions, lifestyle habits, or underlying urinary tract issues. Proper diagnosis and treatment are essential to

Nocardiosis

Nocardiosis is a rare but potentially severe opportunistic bacterial infection caused by species of the Nocardia genus. These gram-positive, filamentous bacteria primarily affect the lungs, central nervous system (CNS), and skin. While nocardiosis can develop in healthy individuals, it predominantly occurs in immunocompromised patients, such as those with HIV/AIDS, organ transplant recipients, and individuals undergoing

Nighttime Sleep Disturbance in Smith-Magenis Syndrome

nighttime sleep disturbance: Smith-Magenis Syndrome (SMS) is a rare genetic disorder characterized by developmental delays, behavioral abnormalities, and distinct sleep disturbances. A hallmark feature of SMS is nighttime sleep disruption, primarily due to an inverted circadian rhythm and abnormal melatonin secretion patterns. Individuals with SMS experience severe difficulty falling and staying asleep, leading to daytime

Niemann Pick Disease Type C

Niemann Pick disease type C (NPC) is a rare, inherited lysosomal storage disorder that affects lipid metabolism, leading to progressive neurological decline. It results from mutations in the NPC1 or NPC2 gene, which disrupt cholesterol and lipid transport within cells, causing toxic accumulation in the brain, liver, and spleen. NPC primarily affects children but can

Niacin Deficiency

Niacin deficiency, also known as vitamin B3 deficiency, is a nutritional disorder that can lead to pellagra, a severe condition characterized by dermatitis, diarrhea, and dementia. Niacin plays a critical role in cell metabolism, energy production, and DNA repair. Without sufficient niacin, vital physiological processes deteriorate, resulting in widespread systemic complications. Understanding Niacin and Its

Neutropenia Secondary to AML Treatment

Neutropenia Secondary to AML Treatment: Neutropenia is a severe reduction in neutrophil count, a type of white blood cell essential for fighting infections. In patients undergoing treatment for acute myeloid leukemia (AML), neutropenia is a frequent and dangerous side effect caused by chemotherapy, radiation therapy, and bone marrow suppression. This condition increases susceptibility to infections,

Neurotrophic Keratitis

Neurotrophic keratitis (NK) is a rare, degenerative corneal disease caused by damage to the trigeminal nerve (cranial nerve V), leading to a loss of corneal sensation. This impairment affects tear production, epithelial integrity, and wound healing, often resulting in corneal ulceration, scarring, and vision loss. Despite being uncommon, NK is a progressive and potentially sight-threatening